Why Microvessels Matter?
Microvessels deliver oxygen and nutrients to every cell in the body, remove waste products, and
regulate inflammation and immune cell trafficking, forming the fundamental network for
sustaining
life.
They consist of arterioles, capillaries, and venules, and each organ possesses its own
specialized
capillary barrier that supports essential physiological functions.
-
Blood-Brain Barrier (BBB)
protects the brain and controls selective exchange -
Blood-Retinal Barrier (BRB)
preserves visual function -
Renal glomerular capillaries
filter waste and regulate systemic homeostasis -
Alveolar capillaries
mediate oxygen and carbon dioxide exchange
Microvessels are not merely small vessels but the structural foundation of organ function and
survival.
At the core of these functions are endothelial cells, which form
barriers, regulate molecular
exchange, and orchestrate inflammation, coagulation, and perfusion.
Thus, endothelial dysfunction directly leads to microvascular
breakdown and represents a common
starting point for many intractable diseases.
What Drives Endothelial Dysfunction?
Endothelial dysfunction arises in pathological conditions such as diabetes, obesity,
infection, inflammation, and ischemia-reperfusion injury, driven by several factors.
Aging amplifies and accumulates these effects, and despite differences in disease settings,
the mechanisms and phenotypes of endothelial dysfunction commonly appear in a similar manner.
CURACLE drug development strategy
SOLVADYS® Platform
Oral small-molecule therapeutics
EAGLES® Platform
Antibody-based biologics
Curacle’s scientific insight began at the time when anti-VEGF therapies were emerging as a new treatment paradigm. While most research focused on suppressing vascular growth, Curacle turned its attention to the possibility of protecting and restoring endothelial cells. This original discovery opened the door to a distinct therapeutic strategy centered on preserving and repairing blood vessels. Building on this foundation, Curacle has since advanced its science into two proprietary platforms. With this innovation, Curacle is pioneering first-in-class therapies across multiple intractable diseases.
With this innovation, Curacle is pioneering first-in-class therapies across multiple intractable diseases.
