Basic concept & significance of Vessel Protector & Zipper

  • Highly effective protector of endothelial dysfunction working independently on multiple mediators
  • Orally applicable to the 1st line and combination therapy for various & intractable vascular related diseases
Endothelial dysfunction due to aging and so other causes leading to hyperpermeability,
inflammation and degeneration plays key roles in pathogenesis of human diseases, including AMD, diabetic retinopathy, stroke, acute lung injury and other inflammatory disorders.

Causes

  • Infection
  • I/R injury
  • Mechanical Stress
  • Hypertension
  • Aging
  • Ischemia
  • Tumor

MultipleMediators

  • Thrombin
  • IL-1β
  • LPS
  • VEGF
  • Bradykinin
  • IL-17
  • MCP-1
  • TNF-α
  • Histamine

EndothelialDysfunction

  • Endothelial Cell Activation
  • Inflammatory Nf-kB Activation
  • Actin stress fiber information & Contraction
  • EC damage & Senescence
  • Loss of junction & Junctional proteins

PathogenicProgression

  • Hyperpermeability
  • Vascular Degeneration
  • Thrombosis
  • Immune cell Recruitment & Activation

DiseaseOutcomes

  • Edema
  • Loss of blood vessels
  • Inflammation
  • Hemorrhage